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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sucroferric oxyhydroxide ： ウィキペディア英語版 Sucroferric oxyhydroxide Sucroferric oxyhydroxide (INN; trade name Velphoro, by Vifor Fresenius Medical Care Renal Pharma) is a non-calcium, iron-based phosphate binder used for the control of serum phosphorus levels in adult patients with chronic kidney disease (CKD) on haemodialysis (HD) or peritoneal dialysis (PD).〔Velphoro (sucroferric oxyhydroxide). Summary of Product Characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002705/WC500175254.pdf/. Accessed 24 October 2014.〕 It is used in form of chewable tablets. == Hyperphosphataemia == In a healthy person, normal serum phosphate levels are maintained by the regulation of dietary absorption, bone formation and resorption, equilibration with intracellular stores, and renal excretion.〔Jha V, Garcia-Garcia G, Iseki K, et al. (2013). “Chronic kidney disease: global dimension and perspectives”. Lancet 382:260–72.〕 When kidney function is impaired, phosphate excretion declines. Without specific treatment, hyperphosphataemia occurs almost universally, despite dietary phosphate restriction and conventional dialysis treatment.〔〔Hutchison AJ, Smith CP, Brenchley PE (2011). “Pharmacology, efficacy and safety of oral phosphate binders”. Nat Rev Nephrol 7:578–89.〕 In patients on dialysis, hyperphosphataemia is an independent risk factor for fractures, cardiovascular disease and mortality.〔Isakova T, Gutierrez OM, Chang Y, et al. (2009). “Phosphorus binders and survival on hemodialysis”. J Am Soc Nephrol 20:388–96.〕〔Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009). “KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)”. Kidney Int Supplement S1–130.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sucroferric oxyhydroxide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.